Aim:
To compare the efficacy of sequentialtherapy (SQT),
for either 10 days, with a 14-day standard triple therapy
(STT).
Methods:
A total of 117 naive H. pylori-positive patients were randomized to receive:SQT
for 10 days (SQT, n=58) including rabeprazole 20 mg twice daily (bid)
associated with amoxicillin 1000 mg bid (early 5 d), followed by rabeprazole 20
mg bid associated with clarithromycin 500 mg bid plus tinidazole 500 mg bid
(last 5 d); STT (n=59) including rabepazole 20 mg bid plus amoxicillin 1000 mg
bid and clarithromycin 500 mg bid for 14 days.
Results:
Eradication rates after SQT-10 were higher than that of after STT at both:
intention to treat (73.5% vs. 57.4%, p=0.035) and per protocol analysis (86.2%
vs. 66.1%, P=0.01)
Conclusions:
This study shows that SQT 10 days is highly effective in H. pylori eradication.
Sequential therapy may have a role as first-line treatment for H. pylori infection.
Keywords:
sequentialtherapy,
standard triple therapy, Helicobacter pylori
