Objective: In peritumoral edema of IV grade glioma,
infiltrating neoplastic cells have been reported, whereas in metastasis,
peritumoral edema consists essentially of vasogenic edema. Minimum apparent
diffusion coefficient (ADC) value can be used to differentiate IV grade glioma
from solitary metastasis on the basis of cellularity levels in the enhancing
tumor and the peritumoral region.
Materials and Methods: 59 cases of including 30 IV grade glioma and 29
solitary metastasis, underwent conventional MRI and diffusion weighted imaging
(DWI) before undergoing treatment in Cho Ray Hospital. The minimum ADC was
measured in the enhancing tumor, peritumoral region, and contralateral normal
white matter. To determine whether there was a statistical difference between
solitary metastasis and IV grade glioma, we analyzed patient age and sex,
minimum ADC value, and ADC ratio of the two groups.
Results: The mean minimum ADC values and mean ADC ratios
in enhancing tumors and the peritumoral regions were significant difference
between the two groups.
Conclusion: DWI can offer diagnostic information to
distinguish between the two groups.
Keywords: Peritumoral dema; Apparent diffusion coefficient; IV
grade glioma; solitary metastasis